Putative functional variants of lncRNA identified by RegulomeDB were associated with knee osteoarthritis susceptibility
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منابع مشابه
Clinical and Pathophysiologic Significance of MRI Identified Bone Marrow Lesions Associated with Knee Osteoarthritis
Knee osteoarthritis (OA) affects the joint beyond just the articular cartilage. Specifically, magnetic resonance imagingidentifiedbone marrow lesions (BML) in the subchondral bone have both clinical and pathophysiological significance.Compared to joint space narrowing on traditional radiographs, the presence of BMLs has been better correlated withseverity of clinical symptoms ...
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Osteoarthritis (OA) is a common disease that has a definite genetic component. Only a few OA susceptibility genes that have definite functional evidence and replication of association have been reported, however. Through a genome-wide association study and a replication using a total of approximately 4,800 Japanese subjects, we identified two single nucleotide polymorphisms (SNPs) (rs7775228 an...
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Genome-wide association studies (GWAS) have identified many common single nucleotide polymorphisms (SNPs) associated with colorectal cancer risk. These SNPs may tag correlated variants with biological importance. Fine-mapping around GWAS loci can facilitate detection of functional candidates and additional independent risk variants. We analyzed 11,900 cases and 14,311 controls in the Genetics a...
متن کاملFrequency of factors associated with knee osteoarthritis.
OBJECTIVE To determine the frequency of factors associated with knee osteoarthritis. METHOD A cross sectional study was conducted in the department of medicine at Liaquat National Hospital Karachi from September 2007 - March 2008 on patients diagnosed with osteoarthritis of knee. One hundred patients of age more than 18 years, and of either gender were consecutively included. Those patients w...
متن کاملAssociation of ADAM12 gene polymorphisms with knee osteoarthritis susceptibility
Previous studies that evaluated the association between a disintegrin and metalloprotease 12 (ADAM12) gene polymorphisms and knee osteoarthritis (KOA) have given controversial and indefinite results. Therefore, we performed a meta-analysis to confirm this correlation. We searched the PubMed, Embase, and SinoMed databases for all papers published up to April 11, 2017. Overall, five different stu...
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ژورنال
عنوان ژورنال: BMC Musculoskeletal Disorders
سال: 2018
ISSN: 1471-2474
DOI: 10.1186/s12891-018-2197-1